Cellular Imaging and Analysis Recent Publications & Scholarly Works
Zhuang Y, Mendes BB, Menon D, Oliveira J, Chen X, Duman FD, Conniot J, Mercado S, Liu X, Zhang SY, Conde J, Hewitt RE, Fairen-Jimenez D. Multiscale Profiling of Nanoscale Metal-Organic Framework Biocompatibility and Immune Interactions. Adv Healthc Mater. 2025 Aug 7:e01809. https://doi.org/10.1002/adhm.202501809
Wills JW, Dabrowska A, Robertson J, Miniter M, Riedle S, Summers HD, Hewitt RE, Fathima A, da Silva AB, Bastos CAP, Micklethwaite S, Keita ÅV, Söderholm JD, Roy NC, Otter D, Jugdaohsingh R, Mastroeni P, Brown AP, Rees P, Powell JJ. Immunocompetent cell targeting by food-additive titanium dioxide. Nat Commun. 2025 Jul 4;16(1):6067. https://doi.org/10.1038/s41467-025-60248-9
Melle, F., Menon, D., Conniot, J., Ostolaza‐Paraiso, J., Mercado, S., Oliveira, J., Chen, X., Mendes, B. B., Conde, J., & Fairen‐Jimenez, D. (2025). Rational Design of Metal &Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy. Advanced Materials. https://doi.org/10.1002/adma.202412757
Gouveia D, Foreman M, Cloup E. Adult-onset neuronal ceroid lipofuscinosis in a smooth-haired dachshund. Vet Rec Case Rep. 2024;e991. https://doi.org/10.1002/vrc2.991
Karttunen J, Kalmar L, Grant A, Ying J, Stewart SE, Wang X, Frankl FK, Williams T. miR-182, miR-221 and miR-222 are potential urinary extracellular vesicle biomarkers for canine urothelial carcinoma. Sci Rep. 2024 Aug 2;14(1):17967. https://doi.org/10.1038/s41598-024-69070-7
Chen, X., Mendes, B. B., Zhuang, Y., Conniot, J., Mercado Argandona, S., Melle, F., Sousa, D. P., Perl, D., Chivu, A., Patra, H. K., Shepard, W., Conde, J., & Fairen-Jimenez, D. (2024). A Fluorinated BODIPY-Based Zirconium Metal & Organic Framework for In Vivo Enhanced Photodynamic Therapy. Journal of the American Chemical Society, 146, Article 2. https://doi.org/10.1021/jacs.3c12416
Melle, F. (2024). Zirconium-based Metal-Organic Frameworks for Advanced Therapy in Cancer [Apollo - University of Cambridge Repository]. https://doi.org/10.17863/CAM.112358
Gu, Z. (2024) Mechanisms of inflammasome activation by bacterial lipopeptides. Thesis submitted for the degree of Master of Philosophy, Department of Veterinary Medicine, University of Cambridge.
Williams-Walker, A. (2024) Investigating the antimicrobial activity of urinary extracellular vesicles.Thesis submitted for the degree of Master of Philosophy, Department of Veterinary Medicine, University of Cambridge.
Parikh, P. (2024) SIENA universal influenza vaccine vector characterisation. Thesis submitted for the degree of Master of Philosophy, Department of Veterinary Medicine, University of Cambridge.
Buhl, D. (2023). "Novel Diagnostic Methods for Rapid Detection and Identification of Bacterial Infections in Bovine Mastitis" Doctoral Thesis Apollo - University of Cambridge Repository. https://doi.org/10.17863/CAM.104369
Franck, C.O., Popov, A.B., Ahmed, I., Hewitt, R.E., Franslau, L., Tyagi, P. and Fruk, L., (2023) A catch-and-release nano-based gene delivery system. Nanoscale horizons. https://doi.org/10.1039/D3NH00269A
Vis, B., Powell, J.J., Hewitt, R.E. (2023). Label-Free Identification of Persistent Particles in Association with Primary Immune Cells by Imaging Flow Cytometry. In: Barteneva, N.S., Vorobjev, I.A. (eds) Spectral and Imaging Cytometry. Methods in Molecular Biology, vol 2635. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3020-4_8
Wills JW, Robertson J, Tourlomousis P, Gillis CMC, Barnes CM, Miniter M, Hewitt RE, Bryant CE, Summers HD, Powell JJ, Rees P. (2023) Label-free cell segmentation of diverse lymphoid tissues in 2D and 3D. Cell Rep Methods. 2023 Feb 2;3(2):100398. https://doi.org/10.1016/j.crmeth.2023.100398
Zuang, Yunhui. (2022). "Zirconium-Based Metal-Organic Frameworks as Drug Delivery Systems".; Doctoral Thesis Apollo - University of Cambridge Repository. https://doi.org/10.17863/CAM.95257
Franck, Christoph. (2022). “Biopolymer-Hybrid Nanomaterials for Vaccine Formulation.” Doctoral Thesis Apollo - University of Cambridge Repository. https://doi.org/10.17863/CAM.89416
Bestwick J.P. (2022) An Investigation of Immunohistochemical markers and serum autoantibodies in cats with chronic biliary tract disease. Thesis submitted for the degree of Master of Philosophy, Department of Veterinary Medicine, University of Cambridge.
Smith, A. A., Corona-Torres, R., Hewitt, R. E., Stevens, M. P., & Grant, A. J. (2022). Modification of avian pathogenic Escherichia coli χ7122 lipopolysaccharide increases accessibility to glycoconjugate antigens.Microbial Cell Factories, 21(1), 1-9. https://doi.org/10.1186/s12934-022-01903-4
Chen X, Zhuang Y, Rampal N, Hewitt R, Divitini G, O'Keefe CA, Liu X, Whitaker DJ, Wills JW, Jugdaohsingh R, Powell JJ, Yu H, Grey CP, Scherman OA, Fairen-Jimenez D. (2021) Formulation of Metal-Organic Framework-Based Drug Carriers by Controlled Coordination of Methoxy PEG Phosphate: Boosting Colloidal Stability and Redispersibility.J Am Chem Soc. 2021 Aug 6. https://doi.org/10.1021/jacs.1c03943.
Wills JW, Verma JR, Rees BJ, Harte DSG, Haxhiraj Q, Barnes CM, Barnes R, Rodrigues MA, Doan M, Filby A, Hewitt RE, Thornton CA, Cronin JG, Kenny JD, Buckley R, Lynch AM, Carpenter AE, Summers HD, Johnson GE, Rees P. (2021) Inter-laboratory automation of the in vitro micronucleus assay using imaging flow cytometry and deep learning. Arch Toxicol. 2021 Jul 10. https://doi.org/10.1007/s00204-021-03113-0.
Vis, B., Powell, J. J., & Hewitt, R. E. (2020). Imaging flow cytometry methods for quantitative analysis of label-free crystalline silica particle interactions with immune cells. AIMS biophysics, 7(3), 144-166. https://doi.org/10.3934/biophy.2020012
Cortés, A., Wills, J., Su, X., Hewitt, R. E., Robertson, J., Scotti, R., . . . Cantacessi, C. (2020). Infection with the sheep gastrointestinal nematode Teladorsagia circumcincta increases luminal pathobionts. Microbiome, 8(1). https://doi.org/10.1186/s40168-020-00818-9
Vis, B., Hewitt, R. E., Monie, T. P., Fairbairn, C., Turner, S. D., Kinrade, S. D., & Powell, J. J. (2020). Ultrasmall silica nanoparticles directly ligate the T cell receptor complex.Proceedings of the National Academy of Sciences of the United States of America, 117(1), 285-291. https://doi.org/10.1073/pnas.1911360117
Wills JW, Robertson J, Summers HD, Miniter M, Barnes C, Hewitt RE, Keita ÅV, Söderholm JD, Rees P, Powell JJ. Image-Based Cell Profiling Enables Quantitative Tissue Microscopy in Gastroenterology.Cytometry A. (2020) Dec;97(12):1222-1237. https://doi.org/10.1002/cyto.a.24042
Riedle S, Wills JW, Miniter M, Otter DE, Singh H, Brown AP, Micklethwaite S, Rees P, Jugdaohsingh R, Roy NC, Hewitt RE, Powell JJ. A Murine Oral-Exposure Model for Nano- and Micro-Particulates: Demonstrating Human Relevance with Food-Grade Titanium Dioxide. Small. (2020) May;16(21):e2000486. https://doi.org/10.1002/smll.202000486