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Department of Veterinary Medicine Research Facilities

 

Chen X, Zhuang Y, Rampal N, Hewitt R, Divitini G, O'Keefe CA, Liu X, Whitaker DJ, Wills JW, Jugdaohsingh R, Powell JJ, Yu H, Grey CP, Scherman OA, Fairen-Jimenez D. (2021) Formulation of Metal-Organic Framework-Based Drug Carriers by Controlled Coordination of Methoxy PEG Phosphate: Boosting Colloidal Stability and Redispersibility. J Am Chem Soc. 2021 Aug 6. doi: 10.1021/jacs.1c03943.

Wills JW, Verma JR, Rees BJ, Harte DSG, Haxhiraj Q, Barnes CM, Barnes R, Rodrigues MA, Doan M, Filby A, Hewitt RE, Thornton CA, Cronin JG, Kenny JD, Buckley R, Lynch AM, Carpenter AE, Summers HD, Johnson GE, Rees P. (2021) Inter-laboratory automation of the in vitro micronucleus assay using imaging flow cytometry and deep learning. Arch Toxicol. 2021 Jul 10. doi: 10.1007/s00204-021-03113-0.

Vis, B., Powell, J. J., & Hewitt, R. E. (2020). Imaging flow cytometry methods for quantitative analysis of label-free crystalline silica particle interactions with immune cells. AIMS biophysics, 7(3), 144-166. doi:10.3934/biophy.2020012

Cortés, A., Wills, J., Su, X., Hewitt, R. E., Robertson, J., Scotti, R., . . . Cantacessi, C. (2020). Infection with the sheep gastrointestinal nematode Teladorsagia circumcincta increases luminal pathobionts. Microbiome, 8(1). doi:10.1186/s40168-020-00818-9

Vis, B., Hewitt, R. E., Monie, T. P., Fairbairn, C., Turner, S. D., Kinrade, S. D., & Powell, J. J. (2020). Ultrasmall silica nanoparticles directly ligate the T cell receptor complex. Proceedings of the National Academy of Sciences of the United States of America, 117(1), 285-291. doi:10.1073/pnas.1911360117

Wills JW, Robertson J, Summers HD, Miniter M, Barnes C, Hewitt RE, Keita ÅV, Söderholm JD, Rees P, Powell JJ. Image-Based Cell Profiling Enables Quantitative Tissue Microscopy in Gastroenterology. Cytometry A. (2020) Dec;97(12):1222-1237. doi: 10.1002/cyto.a.24042.

Riedle S, Wills JW, Miniter M, Otter DE, Singh H, Brown AP, Micklethwaite S, Rees P, Jugdaohsingh R, Roy NC, Hewitt RE, Powell JJ. A Murine Oral-Exposure Model for Nano- and Micro-Particulates: Demonstrating Human Relevance with Food-Grade Titanium Dioxide. Small. (2020) May;16(21):e2000486. doi: 10.1002/smll.202000486.

Vis, B., Hewitt, R. E., Faria, N., Bastos, C., Chappell, H., Pele, L., . . . Powell, J. J. (2018). Non-Functionalized Ultrasmall Silica Nanoparticles Directly and Size-Selectively Activate T Cells. ACS Nano, 12(11), 10843-10854. doi:10.1021/acsnano.8b03363

Rees P, Wills JW, Brown MR, Barnes CM, Summers HD. The origin of heterogeneous nanoparticle uptake by cells. Nat Commun. (2019) May 28;10(1):2341. doi: 10.1038/s41467-019-10112-4.

Riedle, S., Pele, L. C., Otter, D. E., Hewitt, R. E., Singh, H., Roy, N. C., & Powell, J. J. (2017). Pro-inflammatory adjuvant properties of pigment-grade titanium dioxide particles are augmented by a genotype that potentiates interleukin 1β processing. Particle and Fibre Toxicology, 14(1). doi:10.1186/s12989-017-0232-2

Hewitt, R. E., Vis, B., Pele, L. C., Faria, N., & Powell, J. J. (2017). Imaging flow cytometry assays for quantifying pigment grade titanium dioxide particle internalization and interactions with immune cells in whole blood. Cytometry Part A, 91(10), 1009-1020. doi:10.1002/cyto.a.23245

Hewitt, R. E., Robertson, J., Haas, C. T., Pele, L. C., & Powell, J. J. (2017). Reduction of T-Helper Cell Responses to Recall Antigen Mediated by Codelivery with Peptidoglycan via the Intestinal Nanomineral-Antigen Pathway. Front Immunol, 8, 284. doi:10.3389/fimmu.2017.00284

Pele, L. C., Haas, C. T., Hewitt, R. E., Robertson, J., Skepper, J., Brown, A., . . . Powell, J. J. (2017). Synthetic mimetics of the endogenous gastrointestinal nanomineral: Silent constructs that trap macromolecules for intracellular delivery. Nanomedicine, 13(2), 619-630. doi:10.1016/j.nano.2016.07.008